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Posted: 23-Jul-24
Location: La Jolla, California
Salary: Open
Internal Number: 131183
This position will remain open until a successful candidate has been identified.
UCSD Layoff from Career Appointment: Apply by 07/24/2024 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
Special Selection Applicants: Apply by 08/02/2024. Eligible Special Selection clients should contact their Disability Counselor for assistance.
DESCRIPTION
The Moores Cancer Center (MCC) is one of just 57 NCI-designated Comprehensive Cancer Centers in the United States and the only one in San Diego County. As a consortium cancer center, it is a collaborative partnership between the UCSD: encompassing 28 departments, 6 schools (School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, School of Public Health, Jacobs School of Engineering, School of Biological Sciences & the School of Physical Sciences), UCSD Health oncology hospitals and clinics; the basic and public health research and outreach of San Diego State University (SDSU), and the basic and translational research of the La Jolla Institute of Immunology (LJI). These various programs and units are all dedicated to fulfilling the Moores Cancer Center's mission of reducing cancer's burden. As such, it ranks among the top centers in the nation conducting the continuum of cancer research, providing advanced patient care, and serving the community through outreach and education programs. As a top-ranking, future-oriented organization, we offer challenging career opportunities in a fast-paced and innovative environment. Moores Cancer Center follows a progressive philosophy of career-path development for its employees including opportunities for cross-training, professional development, and progressive responsibility.
MCC's mission is to transform cancer care in our catchment area and beyond by driving exceptional scientific discoveries and innovations in prevention, detection, care, and training. MCC will make a global impact on improving health by reducing cancer burden through accelerated discovery and translation, compassionate and interdisciplinary care, education and community engagement, with the foundation of our core values - Excellence, Innovation and Risk-Taking, Collaboration, Diversity and Service.
This is a long-standing NIH funded laboratory focused on understanding the molecular determinants that drive pancreatic cancer development and progression. The lab also works to define therapeutic vulnerabilities in PDAC and uses laboratory-based models to study approaches for early detection, prevention, and development of novel therapeutics for pancreatic cancer. Specific areas of research interest are the DNA damage response and therapeutic vulnerabilities, understanding the complexities of the tumor microenvironment and mechanisms that drive therapeutic resistance, and developing new therapeutics to more effectively target pancreatic cancer.
Under direction of the Principal Investigator, the Senior Scientist will independently drive the scientific direction and research productivity of the lab. This will include making significant innovative contributions pertaining to the development and design of new complex research project and grant writing. Manage and coordinate research collaborations between the Simeone lab and others across the UCSD community and beyond.
Anticipated scientific duties will include partnering with the principal investigator in developing, outlining and refining the strategic directions of the laboratory, designing and overseeing projects, contribute data for publication, and grant writing.
MINIMUM QUALIFICATIONS
Advanced theoretical knowledge and/or Bachelor's Degree in cancer biology with a background in cancer biology, immunology, DNA damage response signaling.
Experience independently isolating bone marrow and blood cells for analysis by flow cytometry, immunoblotting, gene expression and cell adhesion assays.
Experience independently performing and directing in vivo experiments including the injection of growth factors, tumor cells and therapeutics, bleeding and tissue harvesting of mice and in performing minor surgery.
Demonstrated experience in caring for and handling mice for surgical procedures, including anesthesia administration. Experience to maintain animal colony by breeding, genotyping and weaning animals, creating new animal strains and keeping accurate records
Experience independently performing and directing protein analysis techniques including protein determination, ELISA and Magpix assays and protein separation techniques.
Experience independently working with endothelial, myeloid and tumor cell culture, DNA and RNA isolation from culture cells and from tissues,
Connections working at University of California San DiegoUC San Diego is an academic powerhouse and economic engine, recognized as one of the top 8 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom - life is their laboratory. UC San Diego's rich academic portfolio includes six undergraduate colleges, five academic divisions and five graduate and professional schools. The university's award-winning scholars are experts at the forefront of their fields with an impressive track record for achieving scientific, medical and technological breakthroughs.