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The UCSD Department of Pharmacology is one of two basic science units in the School of Medicine where world-class researchers investigate the effects of chemical interventions on biological systems. The faculty are internationally renowned for their strength in elucidating basic cellular and molecular mechanisms of signal transduction that lead to innovative drug target identification and ultimately to cutting edge drug discovery. The faculty also plays a major role in medical and graduate student training, providing educational and programmatic offerings that span several disciplines, and provide diversity to meet the interests of a broad spectrum of students and scholars.
More than one hundred trainees at the graduate student and postdoctoral level, as well as a staff of more than 50 research technicians and department administrators interact closely with the faculty. The diverse mix of ages, backgrounds, and talents creates a robust work environment with challenging career opportunities and a commitment to continued growth potential. We constantly seek to recruit highly motivated, technologically-advanced and interested individuals to become a part of our dynamic exploratory research and educational environment. For more information, please visit our website at http://pharmacology.ucsd.edu.
The Staff Research Associate III will contribute significant and original ideas and methods to research projects and will independently perform a wide variety of experimental research techniques related to cancer biology research. Initiate, develop, implement, and ensure compliance with all required protocols. Independently perform RNA sequencing and cell signaling analyses, cell-sorting, immunofluorescence staining, IHC Scoring and independently collect and analyze the resulting data. Incumbent must be proficient working with genetically engineered mouse models of development of nonalcoholic steatohepatitis and hepatocellular carcinoma, and human cell lines of pancreatic cancer and hepatocellular carcinoma for investigating novel immunotherapeutics and molecular targeted drugs.
In addition, knowledge of cell isolation from specific tissues with magnetic beads and FACS, followed by functional analysis of these cells in the development and progression of nonalcoholic steatohepatitis and hepatocellular carcinoma, is of importance. Responsible for overseeing laboratory management, mouse colony maintenance, maintaining equipment and ensuring that EH&S regulations are met. This position is afforded significant latitude for complex research projects, decision-making and independent judgment.
Advanced theoretical background and practical knowledge in biochemistry, molecular biology, and pharmacology, with particular expertise in cancer biology research as typically attained by a Bachelor's degree, or an equivalent combination of education and experience.
Extensive experience in the generation and analysis of mouse models of cancer, and in the generation and analysis of patient-derived xenografts of different types of human cancer (including orthotopic transplants).
Proven ability to contribute to original project development ideas, experimental design and strategies, as well as their implementation into a variety of research projects.
Experience working with primary human and mouse cancer cells and mouse models of cancer, including genetic models and human xenografts.
Advanced skill, experience, and strong knowledge in a variety of molecular pathology and biochemical techniques including: DNA extraction, RNA isolation, isolation of bacterial plasmids, molecular cloning, tissue culture of human and mouse samples, histological and immunohistochemical analyses, immunofluorescent staining and imaging, cell-sorting, SDS Polyacrylamide and agarose gel electrophoresis, PCR and Western blots.
Proven ability and experience troubleshooting and recommending modifications to procedures and protocols to meet the needs of research projects.
Ability to effectively document complex research procedures, accurately record experimental details and results, perform scientific calculations necessary for data analysis, prepare graphs and figures to summarize results and write reports.
Skilled in the operation, maintenance, and calibration of the laboratory equipment including: the cryostat, the Leica SP5 confocal microscope, FACS sorter, centrifuges, microscopes
UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 8 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom - life is their laboratory. UC San Diego's rich academic portfolio includes six undergraduate colleges, five academic divisions and five graduate and professional schools. The university's award-winning scholars are experts at the forefront of their fields with an impressive track record for achieving scientific, medical and technological breakthroughs.